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By Carl Thompson
January 25, 2021



Axiron is generating a lot of discussion in forums and online review sites due to its innovative application system.

Unlike other testosterone boosters, this unique gel is applied to the armpits where it is absorbed through the skin and released directly into the bloodstream.

It comes highly recommended by doctors and users alike as a convenient way to optimize testosterone levels.

Yet is the perfect solution we’ve all been waiting for?

I have my doubts, so I did a little research on what Axiron can really do. . .

Understanding Axiron

Axiron is classified as a controlled substance (CIII).

It is a clear, colorless gel containing 30 mg testosterone in a 1.5 mL solution of ethanol, isopropyl alcohol, octisalate, and povidone.

One applied to the skin, the alcohol and other ingredients evaporate, leaving the testosterone to be absorbed directly into the bloodstream.

It is designed specifically for men who have little or no testosterone.

Is There Clinical Research?

In a study published by Clinical Endocrinology, Axiron raised testosterone levels to normal range in men with low testosterone. Furthemrore, Axiron treatment improved symptoms associated with low testosterone.

In the 120 day clinical study conducted by over 26 centers, researchers assessed the safety, pharmacokinetics, and efficacy of the 2% testosterone solution when applied to the underarm.
All 155 men started with a 60 mg dose, though this dosage was adjusted as necessary on days 45 and 90.

At the end of the study, 7 out of 10 men experienced an increase in testosterone, enabling subjects to enjoy testosterone levels at a normal range.

Researchers concluded Axiron “provides a treatment option that is efficacious and generally well-tolerated.” [1]

Is Axiron FDA Approved?

Axiron has undergone extensive clinical trials for both safety and effectiveness. It received FDA approval in 2010. [2]

Should You Be Worried About Side Effects?

Axiron is safe when used appropriately. However, it does come with negative side effects such as increased acne or hair growth, headaches, mood changes, and changes in sex drive.

However, you should seek medical help immediately if you experience any of the following negative side effects:

• Allergic reactions (difficulty breathing, hives, swelling, etc.)
• Swelling of the ankles
• Urination problems and dark urine
• Frequent, prolonged, or bothersome erections
• Nausea, stomach pain
• Clay colored stools
• Jaundice (yellowing of the skin or eyes)
• Enlarged, swollen, or painful breasts

Beware of Accidental Exposure
Women and children may become accidentally exposed to testosterone via skin-to-skin contact with Axiron application areas.

Those who come in contact with Axiron should wash immediately with soap and water.

The extra testosterone may cause premature signs of puberty (such as enlarged genitals and pubic hair) in children and abnormal hair growth and increased acne in women.

Should these signs occur, stop using Axiron and consult medical help immediately.

Recommended Usage

Axiron may be FDA approved but it comes with a long list of negative side effects if not used correctly. Consequently, users should pay close attention to the application instructions and only take the amounts recommended by a professional.

Before Using Axiron
Prior to using Axiron, inform your doctor of any medical conditions you may have or any medications you are taking, including vitamins, minerals, and other dietary supplements.

Do not use Axiron if you are allergic to testosterone, have prostate cancer or an enlarged prostate, or have male breast cancer.

Also inform your doctor if you have any of these conditions:

• Diabetes
• Sleep apnea (difficulty breathing during sleep)
• Liver disease or kidney disease

Priming the Pump
Before beginning a new Axiron bottle, prime the pump by gently pressing the pump down 3 times. Do not use any of the solution that comes out during priming and be sure to wash the solution down the sink to avoid accidental exposure to others.

How to Apply Axiron
Axiron should only be applied to the armpits. Do not apply to the scrotum, penis, abdominals, shoulders, or any other body part.

Make sure the armpit is clean, dry, and that there is no broken or irritated skin before applying Axiron.

Apply gel at approximately the same time each morning, preferably after showering or bathing. You can use antiperspirant or deodorant before applying Axiron, but allow at least 2 minutes before using the prescription.

If you accidentally apply deodorant after applying Axiron, dispose of deodorant directly to the trash. This prevents accidental transfer of testosterone on to the deodorant and ensures proper dosage.

Slowly pump Axiron gel into applicator cup. The cup is designed to hold one pump, though it will not be completely full.

Swipe applicator cup under the arm. Depending on your dosage, you may need to make multiple applications to both arms, or just one application to one arm.

Do not apply Axiron with fingers or hands. Wash hands immediately after applying testosterone to avoid accidental exposure.

Avoid splashing into the eyes. If solution comes into contact with the eyes, flush with water. Contact medical help if additional irritation occurs.

Wait at least 2 hours before showering, swimming, or bathing. Exposing the application site to water before then will wash away the testosterone and minimize results.

Axiron is flammable until dry. Avoid smoking or going near an open flame for several minutes after application.

After applying Axiron, immediately wash hands with soap and water to avoid accidental exposure. Then, allow application site to dry before covering with clothing.

To ensure Axiron is working, blood tests and testosterone levels will need to be analyzed frequently. Visit your doctor regularly to ensure best results and reduce side effects.

Missed Dosage
If you miss an application, apply Axiron as soon as you remember, unless it is almost time to apply your next dose. In this case, skip the missed dose and continue with your next scheduled application.

Do not apply more Axiron to make up for the missed dose. Additional applications may result in an overdose and increase side effect risk.

If you take more Axiron than recommended, seek medical attention immediately or call the poison help line at 1-800-222-1222.

Who Can Use Axiron
Axiron is designed specifically for men. It should not be used by women, especially those who are pregnant because the testosterone may cause birth defects.

Older men may have an increased risk of prostate enlargement or cancer. Talk with your doctor about potential risks if you are over 65.

Axiron should not be used by anyone younger than 18 years old. Improper Axiron use may affect bone growth in children.

What Axiron Users are Saying

As with any testosterone booster, Axiron reviews are fairly mixed. Some users loved their results, others did not.

However, Axiron’s positive user reviews definitely inspire confidence in its performance:

“Im taking it now. 1 pump under each arm with 500ius hcg/day. I feel fantastic and have great libido. I get my first labs done on the 15th. You do have to be careful putting it on or you can loose some of the solution. Ive used both androgel and testim. I hated testim.” – Railrider, ThinkSteroids.com

“I have been using Axion for a little over a month. I am 65 years old. About 2 weeks after I started the use of Axiron my energy level was unbelieveable. I feel better than I have felt In several years. I have just started my second bottle of it and will give another opinion when I complete this bottle. So far I am very happy with this product.” – Ike830, Drugs.com

“Started using AXIRON two months ago and I feel great again .. in fact, the libido thing is almost now TOO active .. hee hee .. I can work out again .. stay awake past nine again … make love again .. etc etc … it is slightly difficult to use but just go slow when applying ….” – Bruceyboy, WebMD.com.

Is Axiron Affordable?

If you pay for Axiron without insurance, its retail price is approximately $350 per month. Some insurance companies are willing to cover it, while others do not depending on your policy.

30 Day Trial
With your doctor’s approval, you may try Axiron for 30 days completely free of charge. If after 30 days you and your doctor decide Axiron is not for you, simply fill out the voucher form available at Axiron.com and the manufacturers will pay for your first month’s use.

Additionally, if you’ve already tried Axiron with the 30-day free trial and are not completely satisfied, you can get a voucher for a different testosterone supplement also available at Axiron.com.

Axiron Co-Pay Card
Not all insurance companies cover testosterone prescriptions. Consequently, it can be expensive to pay out of pocket.

Fortunately, the manufacturers provide a co-pay card for eligible patients. The manufacturers cover the co-pay and you’ll only have to pay $25 per month, and it is valid for 11 refills. All you have to do is present the card with your prescription at your local pharmacy.

Patients are not eligible if prescription is paid in part or in full by government funded programs such as Medicare and Medicaid. The co-pay card is only available to US residents.


• FDA-approved
• Clinically proven
• Contains testosterone
• Easy to apply


• May cause negative side effects
• Might not work for everyone
• May cause negative side effects in those accidentally exposed to Axiron
• Expensive retail price

Is Axiron a Good Choice?

Axiron is a great way to increase testosterone levels if you qualify for a prescription. It is clinically proven and safe to use when closely monitored by a physician.

However, not everyone can obtain a prescription and accidental exposure to others is a constant risk users will have to watch out for. The inconvenience of blood work and doctor’s visits may make Axiron too much of a hassle to be worth the investment.


[1] “Newly published study showed Axiron (testosterone) topical solution restored testosterone levels to normal range in hypogonadal men.” Drugs.com. June, 28, 2011. Available from: http://www.drugs.com/clinical_trials/newly-published-study-showed-axiron-testosterone-topical-solution-restored-testosterone-levels-12056.html

[2] “Lilly and Acrux Receive FDA Approval for Axiron (Teststerone) Topical Solution CIII.” Lilly News Room. Nov. 23, 2010. Available from: http://newsroom.lilly.com/releasedetail.cfm?releaseid=532924

Axiron Customer Reviews

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James Says:

I have been useing Axiron for about 1 week and my sex is back even the wife made a comment. And I do have a little more energy. But I would like to no does it stay like this or get better. Istill dont feel like myself.

June 30, 2013 at 5:49 pm

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